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January 1, 2009Journal of Atherosclerosis and ThrombosisOpen Access

Association between Cardio-Ankle Vascular Index and Serum Cystatin C Levels in Patients with Cardiovascular Risk Factor

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Key result

Cardio-ankle vascular index (CAVI) levels significantly correlated with serum cystatin C levels (r = 0.414, p<0.001), indicating an association between arterial stiffness and early renal insufficiency.

Population

206 consecutive patients with cardiovascular risk factors and/or coronary artery disease (CAD)

Design

Cross-sectional

Authors

KNKeijiro NakamuraToho UniversityTITakuo IizukaToho UniversityMTM TakahashiToho University

Discussion

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Implication

CAVI-cystatin C association in high-risk patients is hypothesis-generating; leaves open causality and clinical relevance pending prospective data.

Study Design

Type

Cross-Sectional (n=206)

Multicenter

No

Structured PICO

P
Population
206 patients aged 45-79 years with cardiovascular risk factors and/or coronary artery disease evaluated in a cross-sectional study.
O
Outcome
Correlation between Cardio-Ankle Vascular Index (CAVI) and serum cystatin C levelssurrogate

Main Result

Effect estimate: r = 0.414

p-value: p=<0.001

Arterial stiffness, as measured by CAVI, is significantly correlated with serum cystatin C levels in patients with cardiovascular risk factors, suggesting a link between arterial stiffness and early renal insufficiency.

Limitations

  • Relatively small sample size
  • Histological examination was not conducted for the diagnosis of renal insufficiency, so the cause was not confirmed
  • Patients were mostly elderly and predominantly male, limiting generalizability to younger or female patients
  • Cross-sectional design prevents concluding cause or effect of the relationship between CAVI and cystatin C levels

Cite This Study

Nakamura et al. (2009) conducted a cross-sectional in Cardiovascular risk factors and/or coronary artery disease (n=206). Serum cystatin C levels vs. Normal serum cystatin C levels was evaluated on Correlation between Cardio-Ankle Vascular Index (CAVI) and serum cystatin C levels (r = 0.414, p=<0.001). Cardio-ankle vascular index (CAVI) levels significantly correlated with serum cystatin C levels (r = 0.414, p<0.001), indicating an association between arterial stiffness and early renal insufficiency.

synapsesocial.com/papers/6a3dc306e67a1dc2fe0aee79https://doi.org/10.5551/jat.no687

Topics

Women and heart disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relationship of Cardio-Ankle Vascular Index (CAVI) to Carotid and Coronary Arteriosclerosis2008 · 150 citations
  2. 2Cardio-Ankle Vascular Index is a Candidate Predictor of Coronary Atherosclerosis2007 · 271 citations
  3. 3Estimated Glomerular Filtration Rate and Urinary Albumin Excretion Are Independently Associated with Greater Arterial Stiffness2007 · 198 citations
  4. 4Endothelial Dysfunction Contributes to Renal Function–Associated Cardiovascular Mortality in a Population with Mild Renal Insufficiency2005 · 244 citations
  5. 5Advanced Endothelial Dysfunction in Diabetic Patients with Multiple Risk Factors; Importance of Insulin Resistance2007 · 38 citations