Key result
High-sensitivity cardiac Troponin T values at admission correlated well with CE-MRI infarct mass (r = 0.474; 95% CI 0.331-0.560; P<0.0001), showing superior correlation to a third-generation assay.
Why the study?
Correlations between contrast-enhanced MRI infarct mass and serial high-sensitivity cardiac Troponin T values across different time points needed validation in acute myocardial infarction.
Do serial high-sensitivity cardiac Troponin T values correlate with infarct mass determined by CE-MRI in patients with acute myocardial infarction?
Observational (n=137)
Do serial high-sensitivity cardiac Troponin T values correlate with infarct mass determined by CE-MRI in patients with acute myocardial infarction?
Supports admission hs-cTnT for early infarct size estimation; confirms troponin-MRI associations across time points in acute MI.
AIM: To validate correlations between contrast-enhanced magnetic resonance imaging (CE-MRI) infarct mass and high-sensitivity cardiac Troponin T (hs-cTnT) values at different time points in patients with confirmed acute myocardial infarction (AMI). METHODS AND RESULTS: Patients presenting with AMI and with available CE-MRI between 1 January 2018 and 31 December 2020 were included. Correlation coefficients between hs-cTnT on admission, after 24, 48, 72, and 96 h, and peak hs-cTnT values and CE-MRI infarct mass were calculated. Correlations between hs-cTnT and CE-MRI infarct mass were compared with those of a third generation cTnT assay from a previously published study of our group. A total of 137 patients were included for the present analysis. Median CE-MRI infarct mass was 12,5 g [95% confidence interval (CI): 9.8-16.2 g]. Hs-cTnT values and infarct mass correlated well at all time points including admission (r = 0.474, 95% CI: 0.331-0.560, P < 0.0001), 24 h (r = 0.508, 95% CI: 0.370-0.625, P < 0.0001), 48 h (r = 0.547, 95% CI: 0.404-0.664, P < 0.0001), 72 h (r = 0.489, 95% CI: 0.320-0.628, P < 0.0001), 96 h (r = 0.509, 95% CI: 0.330-0.653, P < 0.001) including peak hs-cTnT values (r = 0.547, 95% CI: 0.416-0.656, P < 0.0001), and maximum absolute delta changes within 96 h (r = 0.507, 95% CI: 0.369-0.622, P < 0.001). Correlations of the third generation assay could be confirmed for hs-cTnT at all time points. A superior correlation with CE-MRI infarct mass was observed for hs-cTnT values on admission. CONCLUSION: Hs-cTnT values at different time points correlate well with CE-MRI infarct mass. Correlations of admission hs-cTnT values are superior to those of a third generation assay.
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Salatzki et al. (2022) conducted an observational in Acute myocardial infarction (AMI) (n=137). High-sensitivity cardiac Troponin T (hs-cTnT) vs. Third generation cTnT assay was evaluated on Correlation between hs-cTnT values on admission and CE-MRI infarct mass (r = 0.474, 95% CI 0.331-0.560, p=<0.0001). High-sensitivity cardiac Troponin T values at admission correlated well with CE-MRI infarct mass (r = 0.474; 95% CI 0.331-0.560; P<0.0001), showing superior correlation to a third-generation assay.
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