Key result
The establishment of the CANFON registry highlights the need to identify shared biochemical abnormalities driving progressive multi-organ dysfunction in patients with Fontan circulation.
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Highlights the importance of the newly established CANFON registry for investigating the elusive biochemical mechanisms driving progressive multi-organ dysfunction in Fontan patients.
I congratulate Roy et al. on establishing CANFON, a national Canadian longitudinal cohort spanning pediatric and adult Fontan patients, at a time when Fontan palliation has extended survival into adulthood(1). Patients with Fontan circulation invariably develop progressive multi-organ dysfunction – frailty, exercise intolerance, chronic hepatic congestion and fibrosis, renal impairment, lymphatic and metabolic derangements – yet the unifying mechanisms remain elusive. Echoing the 2019 American Heart Association (AHA) Statement’s emphasis on Fontan-associated complications, a major knowledge gap persists in identifying shared biochemical abnormalities driving this cascade.
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Ashish H. Shah (2025) conducted an editorial in Fontan circulation. The establishment of the CANFON registry highlights the need to identify shared biochemical abnormalities driving progressive multi-organ dysfunction in patients with Fontan circulation.
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