Key result
Poly(A) inhibited the translation of HeLa cell mRNAs, which was restored by poly(A)-binding protein and eukaryotic initiation factor 4A, whereas vaccinia virus mRNAs were less inhibited.
Population
HeLa cell mRNAs and early and late vaccinia virus (VV) mRNAs in nuclease-treated reticulocyte lysates
Design
Preclinical
Authors
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Vaccinia mRNAs resist poly(A) inhibition more than cellular mRNAs; leaves open whether PABP or eIF4A modulation affects viral replication.
Vaccinia virus mRNAs exhibit relative resistance to poly(A)-mediated translation inhibition compared to cellular mRNAs, a process modulated by poly(A)-binding protein and initiation factors.
Bablanian et al. (1991) studied Vaccinia virus mRNA translation. Poly(A) and initiation factors was evaluated on In vitro mRNA translation. Poly(A) inhibited the translation of HeLa cell mRNAs, which was restored by poly(A)-binding protein and eukaryotic initiation factor 4A, whereas vaccinia virus mRNAs were less inhibited.
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