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June 22, 2017Coronary Artery Disease

Worsening atrioventricular conduction after hospital discharge in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

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Key result

Worsened atrioventricular conduction after STEMI was independently associated with an increased risk of all-cause death (HR 2.005; 95% CI 1.051-3.827; P=0.0348) and major adverse cardiac events.

Why the study?

Does worsened atrioventricular conduction after hospital discharge predict adverse outcomes in patients with STEMI undergoing primary PCI?

Population

2,964 patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary…

Comparison

Worsened atrioventricular conduction after… vs Stable atrioventricular conduction (AVC)

Design

Cohort

Follow-up

3 years

Authors

IKIoanna KosmidouCardio-OncologyBRBjörn RedforsInterventional / Structural CardiologyTMThomas McAndrewLehigh University

Discussion

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Implication

Worsened AVC post-STEMI was associated with higher mortality; leaves open whether ECG surveillance improves risk stratification or outcomes.

Study Design

Type

Cohort (n=2,964)

Structured PICO

Does worsened atrioventricular conduction after hospital discharge predict adverse outcomes in patients with STEMI undergoing primary PCI?

P
Population
2,964 patients with STEMI treated with primary PCI, excluding those with baseline high-grade AV block or pacemaker, followed for 3 years.
E
Exposure
Worsened atrioventricular conduction (AVC) after hospital discharge
C
Comparator
Stable atrioventricular conduction (AVC)
O
Outcome
All-cause death and major adverse cardiac events (composite of death, myocardial infarction, ischemic target vessel revascularization, and stroke) at 3 yearshard clinical

Main Result

Hazard Ratio: 2.005 (95% CI 1.051–3.827)

p-value: p=0.0348

Worsened atrioventricular conduction after hospital discharge in STEMI patients treated with primary PCI is uncommon but independently predicts an increased risk of death and major adverse cardiac events at 3 years.

Cite This Study

Kosmidou et al. (2017) conducted a cohort in ST-segment elevation myocardial infarction (STEMI) (n=2,964). Worsened atrioventricular conduction vs. Stable atrioventricular conduction was evaluated on All-cause death (HR 2.005, 95% CI 1.051-3.827, p=0.0348). Worsened atrioventricular conduction after STEMI was independently associated with an increased risk of all-cause death (HR 2.005; 95% CI 1.051-3.827; P=0.0348) and major adverse cardiac events.

synapsesocial.com/papers/6a3fa21fef8b3439f071c9e8https://doi.org/10.1097/mca.0000000000000525

Topics

STEMI managementPercutaneous coronary intervention
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