Key result
Pt-SampEn outperforms traditional HRV metrics by showing superior resistance to ectopic beat interference.
Why the study?
Ectopic beats can affect heart rate variability (HRV) analysis, but the quantitative relationship between ectopic beat burden and HRV indices has not been investigated in depth.
How does the burden of ectopic beats affect heart rate variability indices?
Observational (n=83)
How does the burden of ectopic beats affect heart rate variability indices?
Pt-SampEn demonstrates better robustness to ectopic beats compared to traditional HRV indices like SDNN and LF/HF.
Answers are grounded in this paper and cite their sources.
Caution advised interpreting traditional HRV with ectopics present; Pt-SampEn robustness leaves open its clinical utility pending validation.
The analysis of heart rate variability (HRV) plays a dominant role in the study of physiological signal variability. HRV reflects the information of the adjustment of sympathetic and parasympathetic nerves on the cardiovascular system and, thus, is widely used to evaluate the functional status of the cardiovascular system. Ectopic beats may affect the analysis of HRV. However, the quantitative relationship between the burden of ectopic beats and HRV indices, including entropy measures, has not yet been investigated in depth. In this work, we analyzed the effects of different numbers of ectopic beats on several widely accepted HRV parameters in time-domain (SDNN), frequency-domain (LF/HF), as well as non-linear features (SampEn and Pt-SampEn (physical threshold-based SampEn)). The results showed that all four indices were influenced by ectopic beats, and the degree of influence was roughly increased with the increase of the number of ectopic beats. Ectopic beats had the greatest impact on the frequency domain index LF/HF, whereas the Pt-SampEn was minimally accepted by ectopic beats. These results also indicated that, compared with the other three indices, Pt-SampEn had better robustness for ectopic beats.
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Zhao et al. (2021) conducted an observational in Normal sinus rhythm and Congestive heart failure (n=83). Ectopic beats vs. Before removal of ectopic beats (or ectopic-free segments) was evaluated on Change rate index (C) of heart rate variability indices (SDNN, LF/HF, SampEn, Pt-SampEn) before and after removal of ectopic beats (p=<0.05). Increasing burdens of ectopic beats significantly distorted traditional heart rate variability indices, particularly the LF/HF ratio, while physical threshold-based sample entropy (Pt-SampEn) demonstrated the greatest robustness to ectopic interference.
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