Key result
Adding ectopic beats reduces entropy, while degree-one interpolation editing outperforms deletion and degree-zero methods.
Why the study?
Ectopic beats are artefacts that limit heart rate variability analysis, and the effects of different editing methods on approximate entropy and sample entropy are unclear.
How do ectopic beats and different editing methods affect approximate entropy and sample entropy in heart rate variability analysis?
How do ectopic beats and different editing methods affect approximate entropy and sample entropy in heart rate variability analysis?
Editing ectopic beats using degree-one interpolation is superior to deletion or degree-zero interpolation for preserving the complexity of heart rate variability entropy measures.
Mishandling ectopic beats may compromise HRV entropy reliability; leaves open standardization of editing methods for clinical use.
Approximate entropy (ApEn) and sample entropy (SampEn) are the promising techniques for extracting complex characteristics of cardiovascular variability. Ectopic beats, originating from other than the normal site, are the artefacts contributing a serious limitation to heart rate variability (HRV) analysis. The approaches like deletion and interpolation are currently in use to eliminate the bias produced by ectopic beats. In this study, normal R–R interval time series of 10 healthy and 10 acute myocardial infarction (AMI) patients were analysed by inserting artificial ectopic beats. Then the effects of ectopic beats editing by deletion, degree-zero and degree-one interpolation on ApEn and SampEn have been assessed. Ectopic beats addition (even 2%) led to reduced complexity, resulting in decreased ApEn and SampEn of both healthy and AMI patient data. This reduction has been found to be dependent on level of ectopic beats. Editing of ectopic beats by interpolation degree-one method is found to be superior to other methods.
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Singh et al. (2011) studied Acute myocardial infarction and healthy (n=20). Ectopic beats editing (deletion, degree-zero, and degree-one interpolation) vs. Unedited data or alternative editing methods was evaluated on Approximate entropy (ApEn) and sample entropy (SampEn). Addition of ectopic beats reduced approximate and sample entropy, while editing by interpolation degree-one method was superior to deletion and degree-zero interpolation.
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