Key result
A high SYNTAX score (≥33) was associated with higher median peaks of post-procedural hs-TnI and CK-MB compared to low/mid scores (<33).
Why the study?
The study investigated the relationship between angiographic complexity of CAD assessed by SYNTAX Score and cardiac biomarker elevation after revascularization procedures.
Does a high SYNTAX score correlate with increased release of cardiac biomarkers after revascularization in patients with stable multivessel CAD?
Observational (n=202)
Single-blind
Does a high SYNTAX score correlate with increased release of cardiac biomarkers after revascularization in patients with stable multivessel CAD?
In patients with stable multivessel CAD, a higher SYNTAX score is independently associated with greater release of cardiac biomarkers following revascularization.
Answers are grounded in this paper and cite their sources.
Higher SYNTAX score was associated with greater biomarker elevation; hypothesis-generating and requires prospective validation before clinical adoption.
This study investigated the relationship between angiographic complexities of coronary artery disease (CAD) assessed by SYNTAX Score synergy between percutaneous coronary intervention with taxus and cardiac surgery score (SYNTAX Score) and cardiac biomarker elevation after revascularization procedures.This is a post-hoc analysis of the medicine, angioplasty or surgery study V study of patients with stable CAD. High-sensitivity troponin 1 (hs-TnI) and creatinine kinase-muscle/brain (CK-MB) were assessed before and after cardiovascular procedures. Baselines SYNTAX Scores (SXScores) were calculated by blinded investigators to patient characteristics.Of the 202 patients studied, the mean SXScore was 21.25 ± 9.24; 40.10 ± 7.09 in the high SXScore group and 19.06 ± 6.61 in low/mid SXscore group (P < .0001). Positive correlations existed between SXScore and median peaks after procedural hs-TnI (r = 0.18, P = .009) and CK-MB (r = 0.24, P = .001) levels. In patients with high SXScores (≥33), the median peaks of post-procedural hs-TnI (P = .034)and CK-MB (P = .004) levels were higher than in low/mid SXScore group (<33).The release of hs-TnI at 6 (P = .002), 12 (P = .008), and 24 hours (P = .039) was higher in high SXScore group than in low/mid SXscore group (<33) as was the release of CK-MB at 6 (P < .0001), 12 (P < .0001), 24 (P = .001), 36 (P = .007), 48 (P = .008), and 72 hours (P = .023). After multivariable analysis, high SXScore was a significant independent predictor of release of CK-MB and hs-TnI peaks higher than the median.The increase in release of cardiac biomarkers was significantly associated with the extent of atherosclerosis identified by the SYNTAX Score.
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Azevedo et al. (2020) conducted an observational in Stable coronary artery disease (n=202). High SYNTAX Score (≥33) vs. Low/mid SYNTAX Score (<33) was evaluated on Median peaks of post-procedural hs-TnI and CK-MB levels (r = 0.18 for hs-TnI; r = 0.24 for CK-MB, p=0.009 for hs-TnI; 0.001 for CK-MB). A high SYNTAX score (≥33) was associated with higher median peaks of post-procedural hs-TnI and CK-MB compared to low/mid scores (<33).
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