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All seven serotypes of the foot and mouth disease virus initiate protein synthesis at two separate AUGs, with the major factor determining AUG usage in vitro being Mg2+ concentration.
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Translation of the foot and mouth disease virus genome in vitro and in vivo indicated that all seven serotypes initiate protein synthesis at two separate AUGs. Sequence analysis of the region surrounding these AUGs has shown that the efficiency with which the initiating AUG is recognized is dependent on the flanking nucleotides. However, in vitro, the major factor determining which AUG is used is the concentration of Mg2+.
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Sangar et al. (1987) studied Foot and mouth disease virus. Mg2+ concentration was evaluated on Protein synthesis initiation at two separate AUGs. All seven serotypes of the foot and mouth disease virus initiate protein synthesis at two separate AUGs, with the major factor determining AUG usage in vitro being Mg2+ concentration.
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