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This research aims to explore the patterns of lymph node metastasis in esophageal squamous cell carcinoma and identify associated factors.

June 29, 2026Aging MedicineOpen Access

Lymph Node Metastasis Pattern and Influencing Factors in Esophageal Squamous Cell Carcinoma

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Retrospective study investigates lymph node metastasis in esophageal cancer, highlighting tumor size and thrombus as key factors.

This research aims to explore the patterns of lymph node metastasis in esophageal squamous cell carcinoma and identify associated factors.
Retrospective analysis of 388 patients with esophageal squamous cell carcinoma undergoing curative resection.
Analysis of clinicopathological characteristics and lymph node metastasis patterns.
Univariate and multivariate analyses were performed to identify risk factors for lymph node metastasis.
144 out of 388 patients (37.11%) had lymph node metastasis.
Tumor diameter ≥ 3 cm was associated with increased risk of LNM (OR = 2.485, 95% CI 1.483–4.165, p = 0.001).
Intravascular tumor thrombus significantly increased risk of LNM (OR = 7.123, 95% CI 3.101–16.362, p < 0.001).

Wang et al. (2026) studied this question.

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