Key result
A molecular docking-based approach identified and evaluated potential natural and synthetic inhibitors of the angiotensin-converting enzyme based on binding affinities and ADME properties.
Why the study?
Hypertension is driven by angiotensin II production via ACE, making ACE a key therapeutic target to identify potential inhibitors from natural and synthetic sources.
Comparison
Potential ACE inhibitors from herbs, other natural sources, and synthetic sources
Design
In silico molecular docking and ADME study
Authors
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Supports preclinical screening of candidates; leaves open clinical translation in hypertension.
This computational study provides insights into the interaction properties and drug-likeness of potential natural and synthetic ACE inhibitors for hypertension.
Attique et al. (2019) studied Hypertension. Potential inhibitors of ACE from herbs, natural sources, and synthetic sources was evaluated on Binding affinities and physicochemical features (ADME). A molecular docking-based approach identified and evaluated potential natural and synthetic inhibitors of the angiotensin-converting enzyme based on binding affinities and ADME properties.
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