Why the study?
Does quinapril pretreatment alter the hemodynamic and hemostatic effects of propofol in renal-hypertensive rats with arterial thrombosis?
Population
Two-kidney, one clip renal-hypertensive rats with induced arterial thrombosis
Comparison
Quinapril followed by propofol infusion vs Propofol alone (implied)
Design
Preclinical
Follow-up
10 days of quinapril pretreatment followed by propofol…
Authors
Loading...
Quinapril may attenuate propofol's prothrombotic effects in hypertensive rat thrombosis; leaves open clinical relevance in humans.
Does quinapril pretreatment alter the hemodynamic and hemostatic effects of propofol in renal-hypertensive rats with arterial thrombosis?
Quinapril pretreatment mitigates propofol's adverse hemostatic effects in hypertensive rats but increases mortality due to potentiated hypotension.
Wojewódzka‐Żeleźniakowicz et al. (2016) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: