Why the study?
Does quinapril affect platelet function in men with mild-to-moderate essential hypertension?
Population
10 white men with untreated mild-to-moderate essential hypertension
Comparison
Quinapril 20 mg twice a day for 4 weeks vs Placebo for 4 weeks
Design
RCT, randomized, crossover design, double-blind
Follow-up
4 weeks per treatment arm
Authors
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Quinapril lowers BP without affecting platelet aggregation; confirms ACEI hemostatic neutrality in mild-moderate hypertension.
Does quinapril affect platelet function in men with mild-to-moderate essential hypertension?
Quinapril effectively lowers blood pressure without adversely affecting platelet function in patients with mild-to-moderate essential hypertension.
Gupta et al. (1991) studied this question.
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