Key result
Quinapril improved impaired platelet function and significantly reduced beta-thromboglobulin in patients with mild to moderate hypertension, unlike nifedipine.
Why the study?
Does quinapril improve platelet function compared to nifedipine in patients with mild to moderate hypertension?
Population
40 patients with mild to moderate hypertension and 20 control subjects.
Comparison
Quinapril, dose escalated to control… vs Nifedipine retard, dose escalated to control…
Design
RCT, randomised to receive either quinapril or nifedipine retard, single-blind
Follow-up
12 weeks
Authors
Loading...
May favor quinapril over nifedipine in hypertensives with platelet dysfunction; extends evidence for ACE-inhibitor class effects on hemostasis.
RCT (n=60)
Single-blind
randomised
Does quinapril improve platelet function compared to nifedipine in patients with mild to moderate hypertension?
The ACE inhibitor quinapril, but not the calcium channel blocker nifedipine, demonstrates beneficial effects on platelet function in patients with mild to moderate hypertension.
Islim et al. (2001) conducted an RCT in mild to moderate hypertension (n=60). Quinapril vs. Nifedipine was evaluated on Platelet aggregation, vascular endothelial function and coagulation system activity. Quinapril improved impaired platelet function and significantly reduced beta-thromboglobulin in patients with mild to moderate hypertension, unlike nifedipine.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: