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June 1, 1999Journal of General Virology

Poly(C)-binding protein interacts with the hepatitis C virus 5' untranslated region.

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Key result

Poly(C)-binding proteins (PCBP-1 and PCBP-2) specifically bind to the complete internal ribosome entry site of the hepatitis C virus 5' untranslated region intracellularly.

Authors

KNK Sp√ ngbergUppsala UniversitySSStefan SchwartzUppsala University

Discussion

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Implication

Hypothesis-generating for PCBP roles in HCV; leaves open therapeutic targeting pending functional validation.

PICO

P
Population
Hepatitis C virus (HCV)
I
Intervention / Comparator
Poly(C)-binding protein (PCBP)-1 and PCBP-2
O
Primary Outcome
Interaction with the hepatitis C virus 5' untranslated region

Cite This Study

ngberg et al. (1999) studied Hepatitis C virus (HCV). Poly(C)-binding protein (PCBP)-1 and PCBP-2 was evaluated on Interaction with the hepatitis C virus 5' untranslated region. Poly(C)-binding proteins (PCBP-1 and PCBP-2) specifically bind to the complete internal ribosome entry site of the hepatitis C virus 5' untranslated region intracellularly.

synapsesocial.com/papers/6a4228766079b66d5eaad579https://doi.org/10.1099/0022-1317-80-6-1371
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterisation of Two Major Cellular Poly(rC)-Binding Human Proteins, Each Containing Three K-homologous (KH) Domains1995 · 205 citations
  2. 2La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate1993 · 498 citations
  3. 3Translational Inhibition in Vitro of Human Papillomavirus Type 16 L2 mRNA Mediated through Interaction with Heterogenous Ribonucleoprotein K and Poly(rC)-binding Proteins 1 and 21998 · 199 citations
  4. 4Requirement of poly(rC) binding protein 2 for translation of poliovirus RNA1997 · 312 citations
  5. 5The La antigen binds 5′ noncoding region of the hepatitis C virus RNA in the context of the initiator AUG codon and stimulates internal ribosome entry site-mediated translation1997 · 275 citations