Key result
Concurrent HIIT and resistance training yields a blunted ~9% VO2 peak gain in T2D versus healthy controls.
Why the study?
It remained unclear whether concurrent high-intensity interval training and resistance training can similarly enhance cardiorespiratory fitness, metabolic, and cardiovascular health markers in T1D or T2D patients compared to healthy individuals.
Does concurrent high-intensity interval training and resistance training improve cardiorespiratory fitness and metabolic health in adults with uncomplicated T1D or T2D compared to healthy controls?
Does concurrent high-intensity interval training and resistance training improve cardiorespiratory fitness and metabolic health in adults with uncomplicated T1D or T2D compared to healthy controls?
Absolute Event Rate: 9% vs 18%
p-value: p=< 0.05
Concurrent HIIT and resistance training improves cardiorespiratory fitness in both T1D and T2D, with T2D patients experiencing additional benefits in insulin sensitivity and body composition despite a blunted VO2peak response compared to healthy controls.
Blunted VO2 peak gains in T2D warrant cautious exercise expectations; leaves open subtype-specific training optimization.
Introduction Cardiorespiratory fitness (CRF), as assessed by VO 2 peak, along with metabolic and cardiovascular health indices, represents the strongest predictors of survival. However, it remains unclear whether concurrent high-intensity interval training (HIIT) and resistance training (RT) can similarly enhance these health markers in patients with type-1 diabetes (T1D) or type-2 diabetes (T2D) compared to healthy individuals. Methods Adults with uncomplicated T1D or T2D and healthy normoglycemic controls matched for sex and age (HC1 and HC2) performed 3 training sessions/week of concurrent HIIT and RT for 12 weeks. Pre- and post-intervention assessments included: lipids and glycemic profile, body composition (dual-energy x-ray absorptiometry) and a cyclo-ergometric cardio-pulmonary exercise test. Results Training improved VO 2 peak, the ventilatory threshold (VT1), maximal workload, ventilation and O 2 pulse, similarly in T1D in HC1 without changes in body composition or glycemic profile. In patients with T2D, training improved insulin sensitivity (HOMA-IR), lean mass, VE/VCO2 slope, VT1 and maximal O 2 pulse, workload and VO 2 peak with reduction in fat mass and visceral adipose tissue (VAT) (all, p < 0.05). However, improvements in VO 2 peak and O 2 pulse were lower than in healthy controls (respectively, T2D: +9%, HC2: +18% and T2D: +6%, HC2: +19%, p < 0.05). Conclusions Both patients with T1D and T2D benefit from combined HIIT and RT by improving CRF with specific adaptations influenced by the presence and type of diabetes. While identical magnitude of achievements were observed in T1D and HC1, T2D patients exhibited lower VO 2 peak and maximal O 2 pulse improvements but associated with notable additional health benefits regarding insulin sensitivity, body composition, visceral adipose tissue and ventilatory efficiency.
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Scoubeau et al. (2024) studied Type-1 or type-2 diabetes. Concurrent high-intensity interval training (HIIT) and resistance training (RT) vs. Healthy normoglycemic controls (HC1 and HC2) was evaluated on VO2 peak improvement (p=< 0.05). Concurrent HIIT and resistance training improved VO2 peak in T2D patients by 9% versus 18% in healthy controls (p<0.05), while T1D patients achieved similar improvements to their controls.
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