Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 30, 2026Current Opinion in Structural BiologyOpen Access

Metabolic disruptions through a three-dimensional genomic lens

View Full Paper
Ask AI
Bookmark
Share

Authors

LTLuis Tenorio-HernándezMFMayra Furlan-Magaril

Discussion

Loading...

Member takes

Overview

Review highlights the role of chromatin architecture in gene expression and metabolic disease risk, indicating new therapeutic avenues.

Key Points

  • This research aims to explore the relationship between chromatin architecture and its impact on gene expression and metabolic diseases.
  • Review of recent literature on mammalian 3D chromatin biology
  • Analysis of epigenetic states and chromatin dynamics
  • Assessment of environmental influences on chromatin organization
  • Chromatin loops connect gene promoters to regulatory elements, impacting gene expression.
  • Dynamic changes in chromatin architecture are influenced by diet and circadian rhythms.
  • Non-coding genetic variants modulate gene expression and contribute to metabolic disease risk.

Cite This Study

Tenorio-Hernández et al. (2026) studied this question.

synapsesocial.com/papers/6a435c08759b888809a528b2https://doi.org/10.1016/j.sbi.2026.103318
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 13D chromatin architecture in cancer: mechanisms of dysregulation and emerging therapeutic strategies2026
  2. 2The influencers' era: how the environment shapes chromatin in 3D2024 · 3 citations
  3. 3Architectural logic of the 3D genome: mechanisms of dysregulation and emerging cancer therapeutics2026
  4. 43D chromatin structure remodelling in cancer2026
  5. 5Navigating the 3D genome at single-cell resolution: techniques, computation, and mechanistic landscapes.2025 · 2 citations