Key result
High early peak creatine kinase (>= 1,500 IU/l) after thrombolysis in anterior AMI patients was associated with significantly lower left ventricular ejection fraction (p < 0.001).
Why the study?
Does the magnitude of early peak CK following thrombolysis predict left ventricular ejection fraction in patients with first anterior AMI?
Population
114 patients with first anterior acute myocardial infarction who had early peak creatine kinase after…
Comparison
High early peak CK after thrombolysis vs Low early peak CK after thrombolysis
Design
Cohort
Follow-up
2 months
Authors
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Peak CK remains a valid marker of infarct size post-thrombolysis; confirms correlation with LVEF despite altered release kinetics.
Observational (n=114)
Does the magnitude of early peak CK following thrombolysis predict left ventricular ejection fraction in patients with first anterior AMI?
p-value: p=<0.001
High early peak creatine kinase after thrombolysis in patients with first anterior AMI remains a strong predictor of poor left ventricular function.
Freimark et al. (2008) conducted an observational in Acute Anterior Myocardial Infarction (n=114). High early peak creatine kinase (>= 1,500 IU/l) vs. Low early peak creatine kinase was evaluated on Left ventricular ejection fraction (LVEF) (p=<0.001). High early peak creatine kinase (>= 1,500 IU/l) after thrombolysis in anterior AMI patients was associated with significantly lower left ventricular ejection fraction (p < 0.001).
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