Key result
Extended septal myectomy with subvalvular interventions linked to ~91% reduction in mid-septal peak gradient.
Why the study?
Indications and outcomes for the surgical treatment of the midventricular form of obstructive hypertrophic cardiomyopathy remain under active discussion.
Does surgical treatment improve hemodynamics and symptoms in patients with midventricular obstructive hypertrophic cardiomyopathy?
Population
25 patients aged 23 to 75 years with midventricular obstructive HCM
Comparison
Surgical treatment outcomes
Design
Observational study
Follow-up
1 year
Authors
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Surgical outcomes for midventricular HCM in small series warrant caution; this Level 5 evidence leaves open the need for prospective trials.
Observational (n=25)
No
Does surgical treatment improve hemodynamics and symptoms in patients with midventricular obstructive hypertrophic cardiomyopathy?
Absolute Event Rate: 3.9% vs 41.7%
p-value: p=<0.001
Surgical treatment, including extended septal myectomy and subvalvular interventions, effectively relieves obstruction and improves symptoms in patients with midventricular hypertrophic cardiomyopathy.
Zainetdinov et al. (2024) conducted an observational in Hypertrophic cardiomyopathy with midventricular obstruction (n=25). Extended septal myectomy and subvalvular interventions vs. Pre-operative baseline was evaluated on Peak gradient in the middle section of the interventricular septum (mmHg) (p=<0.001). Extended septal myectomy combined with subvalvular interventions significantly reduced the peak gradient in the middle section of the interventricular septum from 41.7 to 3.9 mmHg (p<0.001).
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