Key result
Programming Boston Scientific ICDs to the AAI(R) pacing mode resulted in unintended asystole and marked bradycardia following untreated nonsustained ventricular tachycardia in two patients.
Case Report (n=2)
No
Programming specific ICDs to AAI(R) mode to minimize ventricular pacing can lead to unintended asystole and bradycardia following NSVT due to the ventricular tachycardia response phase disabling atrial pacing.
Caution advised programming AAI(R) in select ICDs; leaves open manufacturer-specific risks in larger cohorts.
BACKGROUND: Unnecessary ventricular pacing from cardiac implantable electronic devices has been associated with long-term risks (heart failure, atrial fibrillation, and possibly stroke). Several device programming strategies are available to minimize ventricular pacing, each potentially associated with unintended consequences. Occasionally, the only effective means is to program to the AAI(R) pacing mode. However, in one manufacturer's implantable cardioverter defibrillators (ICDs), the AAI(R) mode has the potential risk of prolonged pacing cessation following a nonsustained ventricular tachycardia (NSVT). METHOD: Patients with ICDs, managed through the Cleveland Clinic device clinic, follow the Heart Rhythm Society consensus document recommendations for device monitoring with remote interrogations (every three months) and yearly in-person evaluations. Clinically significant findings also trigger additional evaluations by the nurse and physician. RESULTS: Two patients having Boston Scientific ICDs (E110 Teligen 100; Boston Scientific Corp., Natick, MA, USA), had asystole and marked bradycardia following untreated NSVT. These pauses in pacing were due to use of the AAI(R) pacing mode. In order to enhance ventricular tachycardia detection, by design atrial pacing is disabled during, and for a time after, an episode of ventricular tachycardia when the device operates in the "ventricular tachycardia response" (VTR) phase. Thus, following spontaneous termination of the NSVT, no pacing occurred in these patients until the VTR period ended. Nonconventional programming was utilized to permit AAI(R) pacing while avoiding these asystolic and bradycardic events during VTR. CONCLUSIONS: Unintended consequences can occur when complex VT detection parameters interact with specific pacing modes. At times, nonconventional programming can avoid these interactions while still achieving effective AAI(R) pacing.
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Egan et al. (2015) conducted a case report in Implantable cardioverter defibrillators programmed to AAI(R) mode (n=2). AAI(R) pacing mode was evaluated on Asystole and marked bradycardia following untreated nonsustained ventricular tachycardia. Programming Boston Scientific ICDs to the AAI(R) pacing mode resulted in unintended asystole and marked bradycardia following untreated nonsustained ventricular tachycardia in two patients.
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