Key result
Myocardial infarction in rats induced distinct regional and temporal patterns of ET-1, ANP, and IGF-1 gene expression, with diastolic wall stress best predicting remote area expression.
Population
Coronary artery-ligated or sham-operated rats
Comparison
Coronary artery ligation vs Sham operation
Design
Preclinical
Follow-up
42 days
Authors
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Rat MI data link diastolic wall stress to remote gene expression; leaves open translation to human postinfarct remodeling.
Myocardial infarction induces distinct regional and temporal patterns of ET-1, ANP, and IGF-1 gene expression that correlate with mechanical load, specifically diastolic wall stress.
Loennechen et al. (2001) studied Myocardial infarction. Coronary artery ligation vs. Sham operation was evaluated on Regional and temporal differences in ET-1, ANP, and IGF-1 gene expression and correlation with LV wall stress. Myocardial infarction in rats induced distinct regional and temporal patterns of ET-1, ANP, and IGF-1 gene expression, with diastolic wall stress best predicting remote area expression.
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