Key result
In young rats, TNF-alpha injection significantly reduced left ventricular injury after coronary ligation compared to PBS (7.9% vs 16.2%, P<0.05), whereas in older rats it induced significant mortality.
Population
Young and old murine and rat models of myocardial infarction and cardiac microvascular endothelial cells
Comparison
TNF-alpha injection vs PBS injection
Design
Preclinical
Authors
Loading...
TNF-α raises post-occlusion mortality in aged rodent hearts; extends cytokine research to age-specific pathways while leaving human translation open.
Absolute Event Rate: 7.9% vs 16.2%
p-value: p=<0.05
Aging-associated downregulation of TNF-alpha receptor pathways impairs cardioprotection and increases mortality after myocardial infarction, which can be reversed by restoring PDGF-B expression.
Cai et al. (2003) studied Myocardial infarction. TNF-alpha vs. PBS was evaluated on Left ventricular injury after coronary ligation (in young rats) (p=<0.05). In young rats, TNF-alpha injection significantly reduced left ventricular injury after coronary ligation compared to PBS (7.9% vs 16.2%, P<0.05), whereas in older rats it induced significant mortality.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: