Key result
Left ventricular diastolic dysfunction in nonvalvular atrial fibrillation was associated with significantly lower left atrial appendage emptying velocity (p=0.028) and lateral wall velocity (p<0.001).
Why the study?
Does left ventricular diastolic dysfunction worsen left atrial appendage function and increase thrombotic potential in patients with nonvalvular atrial fibrillation?
Population
58 patients with chronic nonvalvular atrial fibrillation and preserved left ventricular systolic function
Comparison
Left ventricular diastolic dysfunction (n=30) vs No left ventricular diastolic dysfunction (n=28)
Design
Cross-sectional
Authors
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Diastolic dysfunction may impair LAA function in nonvalvular AF; hypothesis-generating and leaves open effects on thromboembolism.
Cross-Sectional (n=58)
Does left ventricular diastolic dysfunction worsen left atrial appendage function and increase thrombotic potential in patients with nonvalvular atrial fibrillation?
p-value: p=0.028
In patients with nonvalvular atrial fibrillation and preserved LVEF, the presence of LV diastolic dysfunction is associated with decreased LAA function and increased spontaneous echo contrast, suggesting a higher thrombotic risk.
Demirçelik et al. (2014) conducted a cross-sectional in chronic nonvalvular atrial fibrillation (n=58). Left ventricular diastolic dysfunction vs. No left ventricular diastolic dysfunction was evaluated on Left atrial appendage emptying velocity (p=0.028). Left ventricular diastolic dysfunction in nonvalvular atrial fibrillation was associated with significantly lower left atrial appendage emptying velocity (p=0.028) and lateral wall velocity (p<0.001).
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