Why the study?
Does the etiology of atrial fibrillation affect left atrial appendage function and the risk of thrombus formation as assessed by tissue Doppler imaging?
Population
84 patients with permanent atrial fibrillation of various etiologies and 23 controls with sinus rhythm.
Comparison
Assessment of left atrial appendage function… vs Controls with sinus rhythm, and comparison…
Design
Cross-sectional
Key result
In patients with permanent AF, LAA function deteriorated most in mitral stenosis, and LAA area change significantly predicted the presence of thrombi (OR 0.84; 95% CI 0.74-0.95; P=0.005).
Authors
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Etiology may influence LAA thrombus risk assessment in permanent AF; leaves open prospective validation before clinical adoption.
Observational (n=107)
Does the etiology of atrial fibrillation affect left atrial appendage function and the risk of thrombus formation as assessed by tissue Doppler imaging?
Odds Ratio: 0.84 (95% CI 0.74–0.95)
p-value: p=0.005
LAA function impairment in AF varies by etiology, being most severe in mitral stenosis, with LAA area change and PW-Doppler emptying velocity serving as important predictors for SEC or thrombi.
Şahı̇n et al. (2009) conducted an observational in Atrial Fibrillation (n=107). Atrial fibrillation etiologies (mitral stenosis, hypertension, hyperthyroidism) vs. Controls with sinus rhythm was evaluated on Presence of thrombi (predicted by percent of LAA area change) (OR 0.84, 95% CI 0.74-0.95, p=0.005). In patients with permanent AF, LAA function deteriorated most in mitral stenosis, and LAA area change significantly predicted the presence of thrombi (OR 0.84; 95% CI 0.74-0.95; P=0.005).
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