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March 2, 2022Quantitative Imaging in Medicine and SurgeryOpen Access

Evaluating left atrial appendage function in a subtype of non-valvular atrial fibrillation using transesophageal echocardiography combined with two-dimensional speckle tracking

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Key result

TEE speckle tracking shows diffusely decreased LAA deformability and compliance in persistent versus paroxysmal AF.

  • P=0.000
  • n=216

Why the study?

LAA dysfunction is closely associated with AF-related stroke, but few studies have evaluated changes in LAA function across different types of AF.

Does transesophageal echocardiography combined with two-dimensional speckle tracking detect differences in left atrial appendage function between paroxysmal and persistent non-valvular atrial fibrillation?

Population

216 patients with non-valvular AF

Comparison

Different types of AF

Design

Retrospective study

Authors

LWLi WangJFJiali FanZWZixuan Wang

Discussion

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Member takes

Overview

May refine AF subtype phenotyping on TEE speckle tracking; leaves open whether measures predict outcomes or alter management.

Study Design

Type

Observational (n=216)

Structured PICO

Does transesophageal echocardiography combined with two-dimensional speckle tracking detect differences in left atrial appendage function between paroxysmal and persistent non-valvular atrial fibrillation?

P
Population
216 patients with non-valvular atrial fibrillation (paroxysmal and persistent)
I
Intervention
Transesophageal echocardiography (TEE) combined with two-dimensional speckle tracking echocardiography (STE)
C
Comparator
Comparison between persistent atrial fibrillation (per-AF) and paroxysmal atrial fibrillation (par-AF)
O
Outcome
Left atrial appendage (LAA) systolic motion and function, including forward strain values of basal, middle, and top segments, and left atrial appendage mechanical dispersion (LAAMD)surrogate

Main Result

p-value: p=0.000

Transesophageal echocardiography with speckle tracking demonstrates that left atrial appendage deformability and compliance are significantly more impaired in persistent compared to paroxysmal non-valvular atrial fibrillation.

Cite This Study

Wang et al. (2022) conducted an observational in non-valvular atrial fibrillation (n=216). Transesophageal echocardiography combined with two-dimensional speckle tracking vs. Different types of atrial fibrillation (persistent vs paroxysmal) was evaluated on Left atrial appendage systolic motion and function (strain values and mechanical dispersion) (p=0.000). Transesophageal echocardiography with speckle tracking demonstrated that left atrial appendage deformability and compliance are decreased diffusely in persistent AF compared to paroxysmal AF.

synapsesocial.com/papers/6a0662ba3f8bf83a443dd90ahttps://doi.org/10.21037/qims-21-942
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluating the novel parameters for assessing the LAA function and thrombus formation with nonvalvular atrial fibrillation2020 · 17 citations
  2. 2Echocardiography for left atrial appendage structure and function2012 · 64 citations
  3. 3Echocardiographic assessment of the left atrial appendage1999 · 301 citations
  4. 4Atrial myocardial deformation properties are temporarily reduced after cardioversion for atrial fibrillation and correlate well with left atrial appendage function2007 · 40 citations
  5. 5The left atrial appendage: from embryology to prevention of thromboembolism2016 · 78 citations