What is the clinical evidence from this study?

Study design: Other. Population: hypertensive heart failure (n=26). Intervention: Spironolactone and captopril vs. Placebo, SPIRO alone, or CAP alone.

What question did this study set out to answer?

This study aims to evaluate the effects of low-dose spironolactone when combined with captopril on heart failure in a rat model of spontaneous hypertension.

June 1, 2003Journal of Cardiovascular Pharmacology

Combined Effects of Low-dose Oral Spironolactone and Captopril Therapy in a Rat Model of Spontaneous Hypertension and Heart Failure

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Key result

The combination of low-dose oral spironolactone and captopril in a rat model of hypertensive heart failure exerted a significant depressor effect, increased urine output, and decreased urinary protein excretion.

Why the study?

Does the combination of low-dose oral spironolactone and captopril improve hemodynamic and renal parameters in a rat model of spontaneous hypertension and heart failure?

Population

26 spontaneously hypertensive heart failure rats

Comparison

Spironolactone combined with captopril for 12… vs Placebo, spironolactone alone, or captopril alone

Design

Preclinical

Follow-up

12 weeks

Authors

AKAtsushi KambaraScottsdale Community College BHBethany J. HolycrossThe Ohio State University PWPeter K. WungJohns Hopkins University

Discussion

Member takes

Implication

Hypothesis-generating for spironolactone-captopril synergy in hypertensive HF models; leaves open clinical translation.

Key Points

This study aims to evaluate the effects of low-dose spironolactone when combined with captopril on heart failure in a rat model of spontaneous hypertension.
Twenty-six spontaneously hypertensive rats with heart failure were treated with placebo, spironolactone, captopril, or both for 12 weeks.
Doses included 20 mg/kg/d spironolactone and 100 mg/kg/d captopril, with assessments of hemodynamic and biochemical parameters.
Plasma aldosterone levels and urinary parameters were measured to evaluate therapy effects.
Combination treatment with spironolactone and captopril led to a significant increase in urine output compared to captopril alone.
Lower urinary protein excretion was observed in the combination group, indicating improved renal function.
Spironolactone alone did not affect blood pressure or heart parameters, whereas the combination showed greater efficacy than captopril alone.

Structured PICO

Does the combination of low-dose oral spironolactone and captopril improve hemodynamic and renal parameters in a rat model of spontaneous hypertension and heart failure?

Population

26 spontaneously hypertensive heart failure rats treated with placebo, spironolactone, captopril, or both for 12 weeks.

Intervention

Spironolactone (20 mg/kg/d by mouth) combined with captopril (100 mg/kg/d by mouth) for 12 weeks

Comparator

Placebo, spironolactone alone (20 mg/kg/d by mouth), or captopril alone (100 mg/kg/d by mouth)

Outcome

Blood pressure, left ventricular end-diastolic diameter, left ventricular ejection fraction, plasma atrial natriuretic peptide concentration, cardiac fibrosis, urine output, urinary protein excretion, and plasma aldosterone levelsurrogate

The addition of low-dose spironolactone to captopril in a rat model of hypertensive heart failure provides synergistic benefits on blood pressure reduction, diuresis, and renoprotection.

Cite This Study

Kambara et al. (2003) studied hypertensive heart failure (n=26). Spironolactone and captopril vs. Placebo, SPIRO alone, or CAP alone was evaluated. The combination of low-dose oral spironolactone and captopril in a rat model of hypertensive heart failure exerted a significant depressor effect, increased urine output, and decreased urinary protein excretion.

synapsesocial.com/papers/6a4c4271028ea97264ab76b9 https://doi.org/10.1097/00005344-200306000-00002

Topics

Heart failure Hypertension management HFrEF treatment HFpEF management

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Combined Effects of Low-dose Oral Spironolactone and Captopril Therapy in a Rat Model of Spontaneous Hypertension and Heart Failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Combined Effects of Low-dose Oral Spironolactone and Captopril Therapy in a Rat Model of Spontaneous Hypertension and Heart Failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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