Key result
Rapid progression of coronary artery calcification in hypertensive adults was associated with an increased risk of long-term cardiovascular events compared to no progression (HR 2.13; 95% CI 1.12-4.03).
Why the study?
Does progression of coronary artery calcification predict long-term cardiovascular events in asymptomatic hypertensive adults?
Population
210 hypertensive adults, mean age 64 ± 5.6 years, 54% men, free of symptoms or known cardiovascular disease…
Comparison
Progression of coronary artery calcification… vs Zero progression of coronary artery calcification.
Design
Cohort
Follow-up
15 years (mean 11.4 ± 4.4 years)
Authors
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May refine risk stratification in hypertension; hypothesis-generating pending randomized validation of serial imaging.
Cohort (n=210)
Yes
Does progression of coronary artery calcification predict long-term cardiovascular events in asymptomatic hypertensive adults?
Hazard Ratio: 2.13 (95% CI 1.12–4.03)
Absolute Event Rate: 49% vs 25%
p-value: p=0.005
Progression of coronary artery calcification over time is independently associated with an increased risk of long-term cardiovascular events in asymptomatic hypertensive patients.
Shemesh et al. (2013) conducted a cohort in Hypertension (n=210). Rapid progression of coronary artery calcification vs. Zero progression (nonprogressors) was evaluated on First cardiovascular event after the last CT scan (HR 2.13, 95% CI 1.12-4.03, p=0.005). Rapid progression of coronary artery calcification in hypertensive adults was associated with an increased risk of long-term cardiovascular events compared to no progression (HR 2.13; 95% CI 1.12-4.03).
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