Key result
Angiopoietin 2 levels were significantly higher in patients with sepsis and DIC compared to healthy controls (P<0.0001) and better predicted DIC severity than clinical illness scores.
Why the study?
Can Ang-2 plasma levels predict sepsis-associated coagulopathy severity and 28-day mortality in patients with sepsis and suspected DIC?
Population
102 patients with sepsis and suspected disseminated intravascular coagulation at intensive care unit admission
Comparison
Measurement of Angiopoietin 2 plasma levels vs Healthy controls and clinical illness severity…
Design
Cohort
Follow-up
28 days
Authors
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Ang-2 may aid sepsis coagulopathy risk stratification; hypothesis-generating and requires prospective validation before practice change.
Observational (n=102)
Can Ang-2 plasma levels predict sepsis-associated coagulopathy severity and 28-day mortality in patients with sepsis and suspected DIC?
p-value: p=<0.0001
Ang-2 levels are significantly upregulated in sepsis-associated coagulopathy and may serve as a predictive biomarker for DIC severity and 28-day mortality.
Statz et al. (2018) conducted an observational in Sepsis and suspected disseminated intravascular coagulation (DIC) (n=102). Angiopoietin 2 (Ang-2) levels vs. Healthy controls was evaluated on Mean Ang-2 levels in patients with sepsis and DIC compared to healthy controls (p=<0.0001). Angiopoietin 2 levels were significantly higher in patients with sepsis and DIC compared to healthy controls (P<0.0001) and better predicted DIC severity than clinical illness scores.
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