Key result
In 129 hearts with congenital malformations, endocardial fibrosis was associated with mechanical factors and hypoxia, with elastic tissue being a normal component of the fibrosis.
Population
129 hearts with relatively uncomplicated congenital malformations
Design
Case_series
Authors
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May refine histopathological assessment in congenital heart disease; leaves open causal and therapeutic implications.
Observational (n=129)
Endocardial fibro-elastosis in congenital heart disease appears to be driven by mechanical stress and hypoxia, with elastic tissue proliferation being a normal component of the fibrotic response.
Andersen et al. (1956) conducted an observational in Congenital malformations (n=129). Mechanical factors and hypoxia was evaluated on Site and degree of endocardial fibrosis. In 129 hearts with congenital malformations, endocardial fibrosis was associated with mechanical factors and hypoxia, with elastic tissue being a normal component of the fibrosis.
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