Key result
Agents inhibiting Ins(1,4,5)P3 release, such as gentamicin, effectively suppressed the onset of ventricular tachycardia and fibrillation during early reperfusion in rat models.
Why the study?
Do agents inhibiting Ins(1,4,5)P3 release suppress ventricular arrhythmias during ischemia-reperfusion in rat models?
Population
Perfused rat hearts and in vivo rat models of ischemia-reperfusion
Design
Preclinical
Follow-up
early reperfusion (e.g., 2 minutes)
Authors
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Hypothesis-generating for Ins(1,4,5)P3 inhibitors in reperfusion arrhythmias; leaves open clinical translation.
Do agents inhibiting Ins(1,4,5)P3 release suppress ventricular arrhythmias during ischemia-reperfusion in rat models?
Inhibition of Ins(1,4,5)P3 release suppresses ventricular arrhythmias during early ischemia-reperfusion in rat models, highlighting a potential novel antiarrhythmic target.
Du et al. (1995) studied Ventricular arrhythmias during ischemia-reperfusion. Agents inhibiting Ins(1,4,5)P3 release was evaluated on Ventricular tachycardia (VT), ventricular fibrillation (VF), and accumulation of Ins(1,4,5)P3. Agents inhibiting Ins(1,4,5)P3 release, such as gentamicin, effectively suppressed the onset of ventricular tachycardia and fibrillation during early reperfusion in rat models.
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