Key result
Captopril inhibits endothelin-1 secretion from endothelial cells by enhancing nitric oxide production through the accumulation of endogenous bradykinin acting via B2 receptors.
Why the study?
Does captopril inhibit endothelin-1 secretion in endothelial cells?
Population
Endothelial cells
Design
Preclinical
Follow-up
24 hours
Authors
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Should not change captopril use; extends in vitro evidence for bradykinin-NO mediation of endothelial effects.
Does captopril inhibit endothelin-1 secretion in endothelial cells?
Captopril inhibits endothelin-1 secretion in endothelial cells by accumulating endogenous bradykinin and enhancing nitric oxide production via B2 receptors.
Momose et al. (1993) studied this question. Captopril was evaluated on Endothelin-1 secretion. Captopril inhibits endothelin-1 secretion from endothelial cells by enhancing nitric oxide production through the accumulation of endogenous bradykinin acting via B2 receptors.
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