Key result
Changes in stroke work index (HR 0.44 per 500 U increase) and E/e' ratio (HR 2.58 per 5-U increase) during leg-positive pressure stress predicted cardiovascular events in HFrEF patients.
Why the study?
Does noninvasive assessment of preload reserve using a leg-positive pressure maneuver predict adverse cardiovascular events in patients with heart failure with reduced ejection fraction?
Population
120 consecutive patients with heart failure with reduced ejection fraction (HFrEF)
Design
Cohort
Follow-up
median 20 months
Authors
Loading...
Preload stress testing may refine HFrEF risk stratification; hypothesis-generating and requires prospective validation before clinical use.
Cohort (n=120)
Does noninvasive assessment of preload reserve using a leg-positive pressure maneuver predict adverse cardiovascular events in patients with heart failure with reduced ejection fraction?
Hazard Ratio: 0.44
p-value: p=0.001
Noninvasive assessment of contractile and diastolic reserve using a leg-positive pressure maneuver provides significant prognostic value for predicting cardiovascular events in patients with HFrEF.
Matsumoto et al. (2018) conducted a cohort in heart failure with reduced ejection fraction (n=120). leg-positive pressure stress vs. rest was evaluated on adverse cardiovascular events (HR 0.44, p=0.001). Changes in stroke work index (HR 0.44 per 500 U increase) and E/e' ratio (HR 2.58 per 5-U increase) during leg-positive pressure stress predicted cardiovascular events in HFrEF patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: