Key result
CRT 'super-responders' had excellent long-term outcomes, though 14.5% experienced cardiac events over a mean follow-up of 68 months.
Why the study?
What is the long-term incidence of cardiac events in heart failure patients who are 'super-responders' to cardiac resynchronization therapy?
Population
62 'super-responder' patients with LVEF <=0.35 at implantation who achieved LVEF >0.50 at 1 and/or 2 years…
Design
Cohort
Follow-up
mean 68 ± 30 months
Authors
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Residual event risk in CRT super-responders warrants ongoing surveillance; extends response durability data yet leaves open risk stratification.
Cohort (n=259)
Yes
What is the long-term incidence of cardiac events in heart failure patients who are 'super-responders' to cardiac resynchronization therapy?
CRT super-responders have excellent long-term outcomes, but appropriate CRT-D interventions can still occur despite normalized LVEF, highlighting the need for continued monitoring.
Zecchin et al. (2013) conducted a cohort in Heart failure (n=259). Cardiac resynchronization therapy (CRT) 'super-responder' status was evaluated on Cardiac events (hospitalization or death for heart failure, sudden death, or CRT-D appropriate interventions). CRT 'super-responders' had excellent long-term outcomes, though 14.5% experienced cardiac events over a mean follow-up of 68 months.
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