August 19, 2014European Journal of Heart FailureOpen Access

Super-Responders to Cardiac Resynchronization Therapy Remain at Risk for Ventricular Arrhythmias and Benefit from Defibrillator Treatment

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Why the study?

Does the extent of CRT response affect the long-term incidence of appropriate ICD therapy in primary prevention patients?

Structured PICO

Does the extent of CRT response affect the long-term incidence of appropriate ICD therapy in primary prevention patients?

Population

512 patients who underwent primary prevention cardiac resynchronization therapy-defibrillator (CRT-D) implantation.

Intervention

Cardiac resynchronization therapy-defibrillator (CRT-D) implantation, stratified by extent of response (reduction in LV end-systolic volume at 6 months).

Comparator

Comparison between subgroups based on CRT response: negative responders (increased LVESV), non-responders (decreased LVESV 0-14%), responders (decreased LVESV 15-29%), and super-responders (decreased LVESV ≥30%).

Outcome

Incidence of appropriate ICD therapy.hard clinical

Super-responders to CRT remain at significant risk for ventricular arrhythmias over the long term and continue to benefit from ICD treatment despite initial improvement.

Discussion

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Implication

Super-responders to CRT remain at substantial long-term risk for appropriate ICD therapy; leaves open whether response extent modifies arrhythmia incidence in primary prevention.

Cite This Study

Heijden et al. (2014) studied this question.

synapsesocial.com/papers/6a91b07d5d8e1e776dcbd764 https://doi.org/10.1002/ejhf.152

Topics

Ventricular arrhythmias Cardiac device therapy Heart failure HFrEF treatment

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Implication

Super-responders to CRT remain at substantial long-term risk for appropriate ICD therapy; leaves open whether response extent modifies arrhythmia incidence in primary prevention.