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July 10, 2026StressesOpen Access

Modulation of Inflammatory Stress Responses by Agave potatorum Promotes Wound Healing in Diabetic Mice

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Authors

MDMónica Aideé Díaz-RománRRRamiro Ríos-GómezJAJuan José Acevedo‐Fernández

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Overview

Randomized trial evaluates wound healing in diabetic mice treated with Agave potatorum, suggesting therapeutic potential.

Key Points

  • The aim is to evaluate the safety and efficacy of Agave potatorum in modulating inflammatory stress responses to improve wound healing in diabetic mice.
  • Assessed safety using human keratinocytes and fibroblasts, and an acute oral toxicity assay in CD-1 mice.
  • Evaluated anti-inflammatory activity with a TPA-induced ear edema model.
  • Measured wound healing in normoglycemic and alloxan-induced diabetic mice.
  • The hydroalcoholic extract showed low cytotoxicity at therapeutic concentrations.
  • Both the extract and its fractions significantly reduced TPA-induced ear edema (p<0.05).
  • The n-BuOH fraction accelerated wound contraction in diabetic mice starting on day 6.

Cite This Study

Díaz-Román et al. (2026) studied this question.

synapsesocial.com/papers/6a508da76eeac72a437a0f71https://doi.org/10.3390/stresses6030044
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