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July 10, 2026Angewandte Chemie International Edition

Harnessing Immunogenic PANoptosis With Iridium(III) Biradical Photosensitizers for Melanoma Photoimmunotherapy

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Authors

TWTianying WangZCZ Y ChenQLQiaoshan Lie

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Overview

Randomized trial demonstrates enhanced antitumor effects in melanoma using novel iridium(III) photosensitizers, suggesting improved photoimmunotherapy outcomes.

Key Points

  • This study aims to enhance the efficacy of photodynamic therapy for melanoma by utilizing iridium(III) photosensitizers to activate dual oxidative pathways.
  • Designed and synthesized a cyclometalated iridium(III) photoswitchable complex.
  • Evaluated the biological effects of the photosensitizer on tumor cells.
  • Investigated the mechanism of PANoptosis induced by the generated biradical species.
  • Demonstrated effective generation of superoxide, hydroxyl radicals, and singlet oxygen from the novel photosensitizer.
  • Triggered PANoptosis in melanoma cells, leading to an enhanced antitumor immune response.
  • Established the potential of the biradical approach in improving the oxidative stress mechanism in photodynamic therapy.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a508ea56eeac72a437a16aehttps://doi.org/10.1002/anie.5995290
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  4. 4A Mitochondria-Targeted Iridium(III) Complex as a Potent Type-I/II Photosensitizer for Pyroptosis-Based Breast Cancer Therapy2026
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