Key result
Ascending aortic debanding in a mouse model of pressure overload led to rapid regression of left ventricular weight and normalization of cardiac geometry and function by 14 days.
Population
C57Bl/6 mice
Design
Preclinical
Follow-up
14 days
Authors
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Mouse debanding model enables mechanistic reverse remodelling studies; leaves open translation to human aortic stenosis.
Establishment of a reproducible mouse model of reverse cardiac remodelling via ascending aortic banding and debanding, demonstrating normalization of cardiac geometry and function within 14 days.
Bjørnstad et al. (2011) studied Myocardial remodelling / pressure overload. Ascending aortic banding and subsequent debanding was evaluated on Cardiac geometry and function. Ascending aortic debanding in a mouse model of pressure overload led to rapid regression of left ventricular weight and normalization of cardiac geometry and function by 14 days.
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