Key result
Rhythm control, restrictive annuloplasty, or TEER may improve atrial functional MR driven by LA enlargement.
Why the study?
Functional mitral regurgitation caused by left atrial enlargement—termed atrial functional mitral regurgitation—is an underrecognized cause of secondary mitral regurgitation.
Answers are grounded in this paper and cite their sources.
May inform echo-guided therapy for atrial functional MR; leaves open confirmation in larger trials before practice change.
The conventional view holds that functional mitral regurgitation (MR) is caused by restriction of leaflet motion resulting from displacement of the papillary muscle-bearing segments of the left ventricle. In the past decade, evidence has accrued suggesting functional MR can also be caused by left atrial enlargement. This underrecognized cause of secondary MR-atrial functional MR (AF-MR)-is mechanistically linked to annular enlargement, perturbations of annular contraction, and atriogenic leaflet tethering. AF-MR has been described in patients with atrial fibrillation and heart failure with preserved ejection fraction. Preliminary data suggest rhythm control may decrease MR severity in patients with atrial fibrillation. Additionally, several studies have reported reductions in MR and symptomatic improvement with restrictive annuloplasty and transcatheter edge-to-edge repair. This review discusses the pathophysiology, echocardiographic diagnosis, and treatment of AF-MR. AF-tricuspid regurgitation is also discussed.
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Farhan et al. (2022) conducted a review in Atrial functional mitral regurgitation. Atrial functional mitral regurgitation is an underrecognized cause of secondary MR driven by left atrial enlargement, which may improve with rhythm control, restrictive annuloplasty, or TEER.
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