Decreased fibrin gel porosity and fiber mass-length ratio were significantly inversely correlated with the number and severity of coronary artery stenoses (r = -0.723, p<0.001).
Case-Control (n=38)
The formation of tight, rigid fibrin network structures with small pores is associated with premature coronary artery disease and correlates with the severity of coronary stenoses.
Effect estimate: r = -0.723
p-value: p=<0.001
The native fibrin gel structure formed in vitro from plasma samples was examined by liquid permeation of the hydrated fibrin gel networks in 18 men who had suffered a myocardial infarction before the age of 45 years and in 20 control subjects. Patients with an elevated plasma fibrinogen concentration had a considerably lower fibrin gel porosity (permeability coefficient, Ks) compared with patients with a normal plasma fibrinogen level and with controls. The calculated fiber mass-length ratio of the fibrin gel networks was decreased in both patient groups. Gel porosity differed markedly between individuals at a given plasma fibrinogen concentration. Fairly strong inverse correlations were found between plasma orosomucoid level on the one hand and Ks (r = -0.617, p less than 0.01) or fiber mass-length ratio (r = -0.499, p less than 0.05) on the other. The low density lipoprotein (LDL) cholesterol concentration also correlated inversely with Ks (r = -0.471, p less than 0.05) and fiber mass-length ratio (r = -0.522, p less than 0.05). Significant inverse relations, which were independent of plasma fibrinogen and lipoprotein concentrations, were detected between Ks (r = -0.519, p less than 0.05) and calculated fiber mass-length ratio (r = -0.723, p less than 0.001) and number and severity of coronary artery stenoses determined by angiography. A proneness to formation of tight, rigid and space-filling fibrin network structures with small pores thus appears to be associated with premature coronary artery disease.
Fatah et al. (1992) conducted a case-control in Premature coronary artery disease (n=38). Fibrin gel network characteristics (porosity and fiber mass-length ratio) vs. Control subjects was evaluated on Correlation between fibrin gel characteristics and number/severity of coronary artery stenoses (r = -0.723, p=<0.001). Decreased fibrin gel porosity and fiber mass-length ratio were significantly inversely correlated with the number and severity of coronary artery stenoses (r = -0.723, p<0.001).