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July 15, 2026BMC Veterinary ResearchOpen Access

Isolation and pathogenicity of a highly virulent recombinant GIIc subtype PEDV strain

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Authors

JFJinpeng FanLYLiu YWFWenqian Fu

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Overview

Randomized trial shows enhanced pathogenicity in neonatal piglets, highlighting vaccine challenges.

Key Points

  • The study aims to investigate the isolation and pathogenicity of a new recombinant GIIc PEDV strain.
  • Isolated PEDV strain CHjx2025 from diarrheic piglets in Ji’an City, China.
  • Conducted full-length genome sequencing and recombination analysis.
  • Performed in vitro and in vivo experiments to assess virulence.
  • CHjx2025 was identified as a recombinant strain with 49 unique amino acid substitutions.
  • In vitro replication reached 10^6.5 TCID50/mL in Vero cells by 24 hours post-infection.
  • In vivo challenge resulted in 100% mortality in neonatal piglets within 60 hours.

Cite This Study

Fan et al. (2026) studied this question.

synapsesocial.com/papers/6a57234488b21df87548013fhttps://doi.org/10.1186/s12917-026-05714-2
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