Significant tricuspid regurgitation was detected in 6% of echocardiograms, with right ventricle dilation increasing from 29.3% in moderate TR to 81.7% in massive/torrential TR (P<0.001).
Cohort (n=35,088)
Yes
What is the prevalence, etiology, and surgical risk profile of significant tricuspid regurgitation in a large echocardiography cohort?
Significant tricuspid regurgitation is a prevalent condition (6% of echocardiograms) that is predominantly secondary, and a majority of patients with severe or greater TR have high surgical risk, underscoring the potential need for percutaneous interventions.
p-value: p=<0.001
AIMS: To evaluate the burden of tricuspid regurgitation (TR) in a large cohort, determine the right ventricle involvement of patients with TR and determine the characteristics of isolated TR. METHODS AND RESULTS: Prospective study where consecutive patients undergoing an echocardiographic study in 10 centres were included. All studies with significant TR (at least moderate) were selected. We considered that patients with one of pulmonary systolic hypertension >50 mmHg, left ventricular ejection fraction <35%, New York Heart Association III-IV, or older than 85 years, had a high surgical risk. A total of 35 088 echocardiograms were performed. Significant TR was detected in 6% of studies. Moderate TR was found in 69.6%, severe in 25.5%, massive in 3.9%, and torrential in 1.0% of patients. Right ventricle was dilated in 81.7% of patients with massive/torrential TR, in 55.9% with severe TR, and in 29.3% with moderate TR (P < 0.001). Primary TR was present in 7.4% of patients whereas secondary TR was present in 92.6%. Mitral or aortic valve disease was the most common aetiology (54.6%), following by isolated TR (16%). Up to 51.9% of patients with severe, massive, or torrential primary TR and 57% of patients with severe, massive, or torrential secondary TR had a high surgical risk. CONCLUSION: Significant TR is a prevalent condition and a high proportion of these patients have an indication for valve intervention. More than a half of patients with severe, massive, or torrential TR had a high surgical risk. Massive/torrential TR may have implications regarding selection and monitoring patients for percutaneous treatment.
Flórez et al. (Wed,) conducted a cohort in Tricuspid regurgitation (n=35,088). Tricuspid regurgitation severity was evaluated on Right ventricle dilation by TR severity (p=<0.001). Significant tricuspid regurgitation was detected in 6% of echocardiograms, with right ventricle dilation increasing from 29.3% in moderate TR to 81.7% in massive/torrential TR (P<0.001).