Key result
Device-assisted LAA exclusion prevents fatal ischemic complications in AF patients contraindicated to anticoagulation.
Why the study?
Device-assisted left atrial appendage exclusion prevents fatal ischemic complications in atrial fibrillation with contraindications to anticoagulation, but devices vary in safety profiles and device-related complications.
This review summarizes current anatomical considerations, physiological impacts, and clinical outcomes of various epicardial and endocardial devices for left atrial appendage exclusion.
Answers are grounded in this paper and cite their sources.
May support LAA exclusion in anticoagulation-ineligible AF; leaves open long-term effects on homeostasis and cardiac function.
Device-assisted left atrial appendage exclusion plays a crucial role in the prevention of fatal ischemic complications in patients with atrial fibrillation and contraindications to anticoagulation treatment. Various devices with different safety profiles and device-related complications are available in daily practice to perform this procedure. In this review, the anatomy, physiology, and functions of the left atrial appendage were detailed, and all available devices used for epicardial and endocardial exclusion of the left atrial appendage and their clinical outcomes were discussed. Future research should aim to further investigate the long-term effects of left atrial appendage exclusion on body homeostasis, blood coagulation, and cardiac function.
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Karpierz et al. (2024) conducted a review in Atrial fibrillation with contraindications to anticoagulation. Device-assisted left atrial appendage exclusion was evaluated. Device-assisted left atrial appendage exclusion plays a crucial role in preventing fatal ischemic complications in patients with atrial fibrillation contraindicated to anticoagulation.
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