Key result
Laminar flow stimulated membrane hyperpolarization followed by depolarization within 35 to 160 seconds, caused by a flow-activated chloride-selective membrane current in vascular endothelial cells.
Laminar flow activates both K+ and Cl- currents in vascular endothelial cells, with the balance determining the net membrane potential response, which is implicated in the regulation of vascular tone.
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Preclinical data only; leaves open Cl− currents’ role in human flow-mediated vascular tone.
Barakat et al. (1999) studied this question. Laminar flow was evaluated on Endothelial membrane potential and ion channel activation. Laminar flow stimulated membrane hyperpolarization followed by depolarization within 35 to 160 seconds, caused by a flow-activated chloride-selective membrane current in vascular endothelial cells.
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