Key result
Serotonin at 100 micrograms/min constricted large arteries, reducing popliteal artery diameter by 45% (p<0.001), while increasing blood flow by 108 ml/min (p=0.001).
Why the study?
Does serotonin differentially affect large and small vessels in the intact dog hindlimb?
Does serotonin differentially affect large and small vessels in the intact dog hindlimb?
p-value: p=<0.001
Serotonin induces paradoxical large artery constriction (mediated by 5HT2 receptors) and small vessel dilation (increased blood flow) in vivo, which may have implications for occlusive vascular disease.
No takes yet. Share an insight, caveat, or question.
5HT constricts large arteries in the intact canine femoral bed; leaves open differential human vascular responses.
Blackshear et al. (1985) studied this question. Serotonin (5HT) vs. Norepinephrine (NE) was evaluated on Popliteal artery diameter reduction (p=<0.001). Serotonin at 100 micrograms/min constricted large arteries, reducing popliteal artery diameter by 45% (p<0.001), while increasing blood flow by 108 ml/min (p=0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: