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Investigate how varying vascular tone influences the response of small and large vessels to serotonin in the dog foreleg.

January 1, 1959Circulation ResearchOpen Access

The Influence of Tone upon Responses of Small and Large Vessels to Serotonin

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Baseline tone modulates serotonin vascular effects in dogs; leaves open human translation and requires clinical validation.

Investigate how varying vascular tone influences the response of small and large vessels to serotonin in the dog foreleg.
Examined vascular response in the dog foreleg under varying neurogenic tones
Measured dilatation and constriction effects of serotonin on small and large vessels
Serotonin induces net dilatation when small vessels are constricted, while net constriction occurs when small vessels are already dilated.
When small vessels are dilated, serotonin does not further increase their caliber but continues to constrict large vessels.
Conversely, under constricted conditions, serotonin dilates small vessels more effectively than it constricts large vessels, resulting in net dilatation.

Haddy et al. (1959) studied this question.

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