Key result
Elevated levels of IL-6 and TNF-alpha were strongly associated with increased 12-month mortality (P<0.001), and combined high IL-6 and NT-proBNP predicted >7-fold mortality in ADHF.
Why the study?
Do elevated levels of inflammatory cytokines and their polymorphisms predict mortality in patients with acute decompensated heart failure?
Cohort (n=423)
Do elevated levels of inflammatory cytokines and their polymorphisms predict mortality in patients with acute decompensated heart failure?
p-value: p=<0.001
Circulating levels of IL-6 and TNF-alpha, but not their gene polymorphisms, provide important prognostic information for 12-month mortality in patients with acute decompensated heart failure.
No takes yet. Share an insight, caveat, or question.
IL-6 and TNF-α levels may aid ADHF risk stratification; leaves open whether they guide therapy or add value beyond NT-proBNP.
Miettinen et al. (2008) conducted a cohort in Acute Decompensated Heart Failure (ADHF) (n=423). Elevated levels of inflammatory cytokines (IL-6, TNF-alpha, IL-10) was evaluated on 12-month mortality (p=<0.001). Elevated levels of IL-6 and TNF-alpha were strongly associated with increased 12-month mortality (P<0.001), and combined high IL-6 and NT-proBNP predicted >7-fold mortality in ADHF.
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