What question did this study set out to answer?

To investigate the relationship between insulin resistance measured by HOMA-IR and the prognosis of acute pancreatitis.

October 17, 2019Scientific ReportsOpen Access

HOMA-estimated insulin resistance as an independent prognostic factor in patients with acute pancreatitis

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Prospective study identifies insulin resistance as a key prognostic factor for acute pancreatitis severity, indicating serious outcomes.

To investigate the relationship between insulin resistance measured by HOMA-IR and the prognosis of acute pancreatitis.
Prospective study with 269 patients with acute pancreatitis classified by HOMA-IR scores.
Multivariable logistic regression analysis to assess the association between insulin resistance and AP severity.
Receiver operating characteristic analysis to evaluate the predictive ability of HOMA-IR for severe AP.
Higher proportion of severe AP and ICU admissions in insulin-resistant patients (OR 5.95, 95% CI 1.95-18.15, P = 0.002).
HOMA-IR was an independent factor for severe AP (OR 6.72, 95% CI 1.34-33.62, P = 0.020).
AUC of HOMA-IR for predicting severe AP was 0.719 (95% CI 0.59-0.85, P = 0.003).

Cho et al. (2019) studied this question.

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