Key result
Efficient cardiac transgene expression via intracoronary delivery depends on infusion flow rate and requires an intraluminal seal in larger animals, while excessive flow causes myocardial injury.
Why the study?
Does altering intracoronary flow rate and obtaining an intraluminal seal improve successful cardiac gene delivery and affect myocardial injury in piglets and adult rabbits?
Population
Piglets and adult rabbits
Comparison
Adenoviral vectors containing either… vs Varying flow rates and presence versus absence…
Design
Preclinical
Follow-up
approximately 1 week
Authors
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Refining intracoronary flow and seal may enhance gene delivery in animals; leaves open clinical translation for cardiac therapy.
Does altering intracoronary flow rate and obtaining an intraluminal seal improve successful cardiac gene delivery and affect myocardial injury in piglets and adult rabbits?
Optimizing infusion flow rate and achieving an intraluminal seal are critical for efficient catheter-based intracoronary gene delivery while minimizing myocardial injury.
Emani et al. (2003) studied Myocardial gene delivery. Intracoronary adenoviral gene delivery with varying flow rates and balloon inflation vs. Without balloon inflation / varying flow rates was evaluated on Successful transgene delivery to the heart and extent of myocardial injury. Efficient cardiac transgene expression via intracoronary delivery depends on infusion flow rate and requires an intraluminal seal in larger animals, while excessive flow causes myocardial injury.
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