Key result
Each 10 U/mL increase in serum Ec-SOD activity was associated with a 40.4% decrease in the odds of concentric hypertrophy with heart failure (OR 0.596; 95% CI 0.486-0.730).
Why the study?
Relationships between extracellular superoxide dismutase (Ec-SOD) and abnormal left ventricular geometry patterns and heart failure were unknown in patients with cardiovascular disease.
Is serum Ec-SOD activity associated with abnormal left ventricular geometry and heart failure in patients with cardiovascular disease?
Population
1047 patients with cardiovascular disease
Comparison
Serum Ec-SOD activity across LV geometry patterns and heart failure status
Design
Cross-sectional study
Authors
Loading...
Should not yet change HF management; hypothesis-generating for Ec-SOD in LV remodeling.
Cross-Sectional (n=1,047)
Is serum Ec-SOD activity associated with abnormal left ventricular geometry and heart failure in patients with cardiovascular disease?
Odds Ratio: 0.596 (95% CI 0.486–0.73)
Higher serum Ec-SOD activity is independently associated with a lower likelihood of abnormal left ventricular geometry and overt heart failure in patients with cardiovascular disease.
Li et al. (2020) conducted a cross-sectional in cardiovascular disease (n=1,047). Serum Ec-SOD activity vs. Lower serum Ec-SOD activity was evaluated on concentric hypertrophy with HF (OR 0.596, 95% CI 0.486-0.730). Each 10 U/mL increase in serum Ec-SOD activity was associated with a 40.4% decrease in the odds of concentric hypertrophy with heart failure (OR 0.596; 95% CI 0.486-0.730).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: