Key result
Repeated coronary artery embolizations in dogs produced a pronounced decrease in stroke volume and stroke work, an enlarged end-diastolic volume, and a high ESV/EDV ratio.
Why the study?
Do repeated coronary artery embolizations with lycopodium spores alter ventricular volumes and pressures in intact dogs?
Do repeated coronary artery embolizations with lycopodium spores alter ventricular volumes and pressures in intact dogs?
In a canine model, repeated coronary embolization progressively deteriorates myocardial performance, with the ESV/EDV ratio serving as the most sensitive functional indicator.
Answers are grounded in this paper and cite their sources.
This embolization model in dogs may inform HF progression mechanisms; leaves open translation to clinical practice.
The progressive changes in ventricular volumes and pressures created by repeated coronary artery embolizations with lycopodium spores were studied in fifteen intact dogs. In eight of the animals SV increased over control values following the initial embolization. Subsequent embolizations produced a pronounced decrease in SV and SW, an enlarged EDV, and a high ESV/EDV ratio. Left ventricular systolic pressure fell as EDP rose. The progressive increase observed in the ESV/EDV ratio between successive embolizations was the most sensitive functional expression of the deteriorating myocardial performance.
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Wong et al. (1965) studied Coronary artery embolization (n=15). Repeated coronary artery embolizations with lycopodium spores vs. Control values (baseline) was evaluated on Progressive changes in ventricular volumes and pressures. Repeated coronary artery embolizations in dogs produced a pronounced decrease in stroke volume and stroke work, an enlarged end-diastolic volume, and a high ESV/EDV ratio.
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